Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

作者：Wada Taeko; Kikuchi Jiro; Furukawa Yusuke^*

来源：EMBO Reports, 2012, 13(2): 142-149.

DOI：10.1038/embor.2011.247

• acetylation
• DGCR8
• histone deacetylase
• microRNA
• miRNA processing

Relatively little is known about the regulatory mechanisms of the Drosha/DGCR8 complex, which processes miRNAs at the initial step of biogenesis. We found that histone deacetylase 1 (HDAC1) increases the expression levels of mature miRNAs despite repressing the transcription of host genes. HDAC1 is an integral component of the Drosha/DGCR8 complex and enhances miRNA processing by increasing the affinity of DGCR8 to primary miRNA transcripts via deacetylation of critical lysine residues in the RNA-binding domains of DGCR8. This finding suggests that HDACs have two arms for gene silencing: transcriptional repression by promoter histone deacetylation and post-transcriptional inhibition by increasing miRNA abundance.

• 出版日期2012-1