A highly efficient heterogeneous copper-catalyzed Chan-Lam coupling between thiols and arylboronic acids leading to diaryl sulfides under mild conditions

作者：Lin, Yang; Cai, Mingzhong^*; Fang, Zhigiang; Zhao, Hong^*

来源：Tetrahedron, 2016, 72(23): 3335-3343.

DOI：10.1016/j.tet.2016.04.063

• Chan-Lam coupling
• Supported copper catalyst
• Diaryl sulfide
• MCM-41
• Heterogeneous catalysis

The heterogeneous Chan-Lam coupling reaction between thiols and arylboronic acids was achieved in EtOH at room temperature in the presence of 5 mol % of MCM-41-immobilized 1,10-phenanthrolinecopper(II) complex [MCM-41-1,10-Phen-CuSO4] with n-Bu4NOH (40% aq) as base under O-2 atmosphere, yielding a variety of unsymmetrical diaryl sulfides in good to excellent yields under mild and green conditions. The new heterogeneous copper complex can easily be prepared by a simple procedure from commercially readily available and inexpensive reagents, and recovered by a simple filtration of the reaction solution and recycled for at least eight times without significant loss of catalytic activity.

• 出版日期2016-6-9
• 单位广东药科大学; 江西师范大学