Antiprotozoal assessment and phenolic acid profiling of five Fumaria (fumitory) species

作者：Orhan Ilkay Erdogan^*; Ozturk Nilgun; Sener Bilge

来源：Asian Pacific Journal of Tropical Medicine, 2015, 8(4): 283-286.

DOI：10.1016/S1995-7645(14)60331-X

• Fumaria
• Fumitory
• Antiprotozoal
• Malaria
• Trypanosomiasis
• Phenolic acid

Objective: To explore some Fumaria species which were recorded to be traditionally used against malaria and other protozoal diseases. Methods: Consequently, in the current study. antiprotozoal effect of the ethanol extracts obtained from five Fumaria species (Fumaria densiflora, Fumaria cilicica, Fumaria rostellata, Fumaria kralikii, and Fun:aria parviflora) was investigated against the parasites; Plasmodium falciparum (malaria) and Tryanosoma bruceirhodesiense (human African trypanosomiasis) at 0.81 and 4.85 mu g/mL concentrations. Results: Among them, Fumaria densiflora extract exerted the highest antiplasmodial (93.80%) and antitrypanasomal effect (55.40%). while the ethanol extracts of Fumaria kralikii (43.45%) and Fumaria rostellata (41.65%) showed moderate activity against Plasmodium falciparum. Besides, phenolic acid contents of the extracts were analyzed using high performance liquid chromatography (HPLC) and trans-cinnamic (4.32 mg/g) and caffeic (3.71 mg/g) acids were found to be the dominant phenolic acids in Fumaria densiflora. Conclusions: According to our results. Fumaria densiflora deserve further study for its promising antiprotozoal activity.

• 出版日期2015-4