Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS

作者：Ochi Tsunehiro; Kawaguchi Takumi; Nakahara Takashi; Ono Masafumi; Noguchi Shuhei; Koshiyama Yuichi; Munekage Kensuke; Murakami Eisuke; Hiramatsu Akira; Ogasawara Mitsunari^*; Hirose Akira; Mizuta Hiroshi; Masuda Kosei; Okamoto Nobuto; Suganuma Narufumi; Chayama Kazuaki; Yamaguchi Masahiro; Torimura Takuji; Saibara Toshiji

来源：Scientific Reports, 2017, 7(1): 10146.

DOI：10.1038/s41598-017-09256-4

Glucose intolerance frequently develops in accordance with the progression of chronic liver disease. However, differences in the characteristics of glucose intolerance between patients with nonalcoholic fatty liver disease (NAFLD) and those with chronic hepatitis C (C-CH) remain incompletely understood. To clarify these differences, patients with NAFLD (n = 37) and C-CH (n = 40) were evaluated with a continuous glucose monitoring system (CGMS). In the patients with NAFLD, Maximum blood glucose concentration and blood glucose swings were significantly correlated with hepatic fibrosis markers. In the patients with C-CH, however, those two CGMS parameters were negatively correlated with the serum albumin (ALB) concentration. Furthermore, in the patients with C-CH with an ALB concentration of <= 4.0 g/dl, those two CGMS parameters were negatively correlated with the ALB concentration with greater statistical significance. In conclusion, obvious differences in the characteristics of glucose intolerance between patients with NAFLD and those with C-CH were clarified. In patients with NAFLD, glucose intolerance gradually progressed in accordance with the progression of hepatic fibrosis. In those with C-CH, glucose intolerance suddenly developed upon the appearance of hypoalbuminaemia.

• 出版日期2017-8-31