Adsorption of Oligo-DNA on Magnesium Aluminum-Layered Double Hydroxide Nanoparticle Surfaces: Mechanistic Implication in Gene Delivery

作者：Andrea, Kori A.; Wang, Li^*; Carrier, Andrew J.; Campbell, Melanie; Buhariwalla, Margaret; Mutch, MacKenzi; MacQuarrie, Stephanie L.; Bennett, Craig; Mkandawire, Martin; Oakes, Ken; Lu, Mingsheng^*; Zhang, Xu^*

来源：Langmuir, 2017, 33(16): 3926-3933.

DOI：10.1021/acs.langmuir.6b04172

• DRUG-DELIVERY
• GOLD NANOPARTICLES
• CANCER-THERAPY
• POLYETHYLENE-GLYCOL
• INTERCALATION
• NANOHYBRIDS
• SYSTEMS
• SIRNA
• OLIGONUCLEOTIDES
• SPECTROSCOPY

Magnesium aluminum-layered double-hydroxide nanoparticles (LDH NPs) are promising drug-delivery vehicles for gene therapy, particularly for siRNA interference; however, the interactions between oligo-DNA and LDH surfaces have not been adequately elucidated. Through a mechanistic study, oligo-DNA initially appears to rapidly bind strongly to the LDH outer surfaces through interactions with their phosphate backbones via ligand exchange with OH- on Mg2+ centers and electrostatic forces with Al3+. These initial interactions might precede diffusion into interlayer spaces, and this knowledge can be used to design better gene therapy delivery systems.

• 出版日期2017-4-25
• 单位淮海工学院; 浙江工商大学