Adenosine A(2A) receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent

作者：Gandia Jorge; Morato Xavier; Stagljar Igor; Fernandez Duenas Victor^*; Ciruela Francisco

来源：Behavioural Brain Research, 2015, 288: 103-106.

DOI：10.1016/j.bbr.2015.04.001

• GPR37
• Parkinson's disease
• Pael-R
• Tremulous jaw movement
• Orphan receptor

GPR37, also known as parkin associated endothelin-like receptor (Pael-R), is an orphan GPCR that aggregates intracellularly in a juvenile form of Parkinson's disease. However, little is known about the function of this orphan receptor. Here, using a model for parkisonian tremor, the pilocarpine-induced tremulous jaw movements (TJMs), we show that the deletion of GPR37 attenuated the TJMs in response to this cholinomimetic. Interestingly, the control that adenosine A(2A) receptor exerted over TJMs was lost in the absence of GPR37, thus pointing to a pivotal role of this orphan receptor in the adenosinergic control of parkinsonian tremor.

• 出版日期2015-7-15