Alzheimer%26apos;s disease patients not carrying the apolipoprotein E epsilon 4 allele show more severe slowing of oscillatory brain activity

作者：de Waal Hanneke^*; Stam Cornelis J; de Haan Willem; van Straaten Elisabeth C W; Blankenstein Marinus A; Scheltens Philip; van der Flier Wiesje M

来源：Neurobiology of Aging, 2013, 34(9): 2158-2163.

DOI：10.1016/j.neurobiolaging.2013.03.007

• Alzheimer%26apos
• s disease
• APOE genotype
• Resting-state EEG
• Quantitative analysis

The objective of this study was to quantitatively assess the relationship between apolipoprotein (APOE) genotype and electroencephalographic oscillatory brain dynamics in Alzheimer%26apos;s disease (AD) patients and control subjects and its regional distribution. We obtained resting-state electroencephalographs of 320 AD patients and 246 control subjects, categorized into APOE epsilon 4 carriers and noncarriers. Peak frequency and relative power in 4 different frequency bands were calculated. We tested the associations between APOE genotype and relative power in 4 brain regions. Peak frequency was comparable in APOE epsilon 4 carrying and noncarrying control subjects, but lower in APOE epsilon 4 noncarrying AD patients. In control subjects, APOE epsilon 4 carriers had a different regional distribution of alpha power than noncarriers. We found no APOE effect in beta, delta, and theta bands. In AD, APOE epsilon 4 noncarriers had lower alpha and higher delta power than carriers. This difference was most pronounced in the parieto-occipital region. In the theta band, APOE epsilon 4 noncarriers had a different regional distribution of power compared with carriers. In conclusion, the most pronounced effect of genotype was seen in AD patients, and APOE epsilon 4 noncarriers showed slower activity, especially in parieto-occipital regions.

• 出版日期2013-9