A 4-Year, Open-Label, Multicenter, Randomized Trial of Genotropin (R) Growth Hormone in Patients with Idiopathic Short Stature: Analysis of 4-Year Data Comparing Efficacy, Efficiency, and Safety between an Individualized, Target-Driven Regimen and Standard Dosing

作者：Counts Debra R^*; Silverman Lawrence A; Rajicic Natasa; Geffner Mitchell E; Newfield Ron S; Thornton Paul; Carakushansky Mauri; Escobar Oscar; Rapaport Robert; Levitsky Lynne; Rotenstein Deborah; Hey Hadavi Judith; Wajnrajch Michael P

来源：Hormone Research in Paediatrics, 2015, 84(2): 79-87.

DOI：10.1159/000381642

• Cost effectiveness
• Clinical trial
• Growth hormone
• Dose of growth hormone
• Height prediction model
• Short stature

Background/Aims: Growth hormone (GH) treatment regimens for children with non-GH-deficient, idiopathic short stature (ISS) have not been optimized. To compare the efficacy, efficiency, and safety of an individualized, target-driven GH regimen with standard weight-based dosing after 4 years of treatment. Methods: This is a 4-year, open-label, multicenter, randomized trial comparing individualized, formula- based dosing of Genotropin (R) versus a widely used ISS dose of Genotropin (R). Subjects were prepubertal, had a bone age of 3-10 years for males and 3-9 years for females, were naive to GH treatment, and had a height standard deviation score (Ht SDS) of -3 to -2.25, a height velocity <25th percentile for their bone age, and peak stimulated GH > 10 ng/ml. After the first 2 years, the individualized-dosing group was further randomized to either 0.18 or 0.24 mg/kg/week. Results: At 4 years, subjects in all treatment regimens achieved similar average height gains of + 1.3 SDS; however, the individualized dosing regimen utilized less GH to achieve an equivalent height gain. Conclusion: Individualized, formula-based GH dosing, followed by a dose reduction after 2 years, provides a more cost-effective growth improvement in patients with ISS than currently employed weight-based regimens.

• 出版日期2015