Detailed assessments of childhood adversity enhance prediction of central obesity independent of gender, race, adult psychosocial risk and health behaviors

作者：Davis Cynthia R^*; Dearing Eric; Usher Nicole; Trifiletti Sarah; Zaichenko Lesya; Ollen Elizabeth; Brinkoetter Mary T; Crowell Doom Cindy; Joung Kyoung; Park Kyung Hee; Mantzoros Christos S; Crowell Judith A

来源：Metabolism-Clinical and Experimental, 2014, 63(2): 199-206.

DOI：10.1016/j.metabol.2013.08.013

• Central obesity
• Childhood adversity
• Psychosocial risk factors
• Modifiable risk factors

Objective. This study examined whether a novel indicator of overall childhood adversity, incorporating number of adversities, severity, and chronicity, predicted central obesity beyond contributions of %26quot;modifiable%26quot; risk factors including psychosocial characteristics and health behaviors in a diverse sample of midlife adults. The study also examined whether the overall adversity score (number of adversities x severity x chronicity) better predicted obesity compared to cumulative adversity (number of adversities), a more traditional assessment of childhood adversity. %26lt;br%26gt;Materials/Methods. 210 Black/African Americans and White/European Americans, mean age = 45.8; +/- 3.3 years, were studied cross-sectionally. Regression analysis examined overall childhood adversity as a direct, non-modifiable risk factor for central obesity (waist hip ratio) and body mass index (BMI), with and without adjustment for established adult psychosocial risk factors (education, employment, social functioning) and heath behavior risk factors (smoking, drinking, diet, exercise). %26lt;br%26gt;Results. Overall childhood adversity was an independent significant predictor of central obesity, and the relations between psychosocial and health risk factors and central obesity were not significant when overall adversity was in the model. Overall adversity was not a statistically significant predictor of BMI. %26lt;br%26gt;Conclusions. Overall childhood adversity, incorporating severity and chronicity and cumulative scores, predicts central obesity beyond more contemporaneous risk factors often considered modifiable. This is consistent with early dysregulation of metabolic functioning. Findings can inform practitioners interested in the impact of childhood adversity and personalizing treatment approaches of obesity within high-risk populations. Prevention/intervention research is necessary to discover and address the underlying causes and impact of childhood adversity on metabolic functioning.

• 出版日期2014-2