A novel polymer microneedle fabrication process for active fluidic delivery

作者：Cordovez Bernardo; Chung Aram J; Mak Michael; Erickson David^*

来源：Microfluidics and Nanofluidics, 2011, 10(4): 785-791.

DOI：10.1007/s10404-010-0709-x

• Implantable drug delivery
• Microfluidics
• Polyimide
• Rapid prototyping
• Electrochemistry

In this article, we explore a new fabrication process for a flexible, all polymer, active fluidic delivery system, incorporating a fusion of laser micromachining and microfabrication techniques as well as rapid prototyping technology. Here, we show selective fluidic delivery from isolated microchannels through an electrochemically driven pumping reaction, demonstrate the dispensing of dose volumes up to 5.5 mu l, and evaluate the device's performance in terms of its delivery speed and ejection efficiency. Finally, we move this work toward an implantable microfluidic drug delivery device by investigating the device's biocompatibility through a statistical approach that overviews the viability of bovine aortic endothelial cells on polyimide and silicon substrates.

• 出版日期2011-4