Antiplasmodial and cytotoxic activities of Striga asiatica and Sauropus spatulifolius extracts, and their isolated constituents

作者：Zou Ying Shu; Foubert Kenn; Tuenter Emmy; Lemiere Filip; Cos Paul; Maes Louis; Smits Jan M M; de Gelder Rene; Apers Sandra; Pieters Luc^*

来源：Phytochemistry Letters, 2013, 6(1): 53-58.

DOI：10.1016/j.phytol.2012.10.018

• Striga asiatica
• Sauropus spatulifolius
• N-Hydroxyethyl-2-acetylpyrrole
• N-(3-Carboxypropyl)-2-acetylpyrrole
• Sauropic acid
• Plasmodium falciparum

A phytochemical investigation of Striga asiatica and the leaves of Sauropus spatulifolius revealed seventeen compounds, three of which were reported for the first time from nature, i.e. two alkaloids N-hydroxyethyl-2-acetylpyrrole, N-(3-carboxypropyl)-2-acetylpyrrole, and 2-(4-hydroxy-2,2,6-trimethylcyclohexyl)acetic acid, for which the name sauropic acid was adopted. Their structures were established spectroscopically and by single-crystal X-ray diffraction analysis. All extracts and isolates were evaluated for antiplasmodial activity against Plasmodium falciparum strain K1 and for cytotoxicity against MRC-5 cells.

• 出版日期2013-2