A genome-wide association study yields five novel thyroid cancer risk loci

作者：Gudmundsson Julius; Thorleifsson Gudmar; Sigurdsson Jon K; Stefansdottir Lilja; Jonasson Jon G; Gudjonsson Sigurjon A; Gudbjartsson Daniel F; Masson Gisli; Johannsdottir Hrefna; Halldorsson Gisli H; Stacey Simon N; Helgason Hannes; Sulem Patrick; Senter Leigha; He Huiling; Liyanarachchi Sandya; Ringel Matthew D; Aguillo Esperanza; Panadero Angeles; Prats Enrique; Garcia Castano Almudena; De Juan Ana; Rivera Fernando; Xu Li; Kiemeney Lambertus A

来源：Nature Communications, 2017, 8(1): 14517.

DOI：10.1038/ncomms14517

The great majority of thyroid cancers are of the non-medullary type. Here we report findings from a genome-wide association study of non-medullary thyroid cancer, including in total 3,001 patients and 287,550 controls from five study groups of European descent. Our results yield five novel loci (all with P-combined <3 x 10(-8)): 1q42.2 (rs12129938 in PCNXL2), 3q26.2 (rs6793295 a missense mutation in LRCC34 near TERC), 5q22.1 (rs73227498 between NREP and EPB41L4A), 10q24.33 (rs7902587 near OBFC1), and two independently associated variants at 15q22.33 (rs2289261 and rs56062135; both in SMAD3). We also confirm recently published association results from a Chinese study of a variant on 5p15.33 (rs2736100 near the TERT gene) and present a stronger association result for a moderately correlated variant (rs10069690; OR = 1.20, P = 3.2 x 10(-7)) based on our study of individuals of European ancestry. In combination, these results raise several opportunities for future studies of the pathogenesis of thyroid cancer.

• 出版日期2017-2-14