Associations between plasma total homocysteine, blood pressure stages and pulse wave velocity in Chinese rural community population

作者：Qian, Geng; Zeng, Long-Huan; Liu, Yu-Qi; Cao, Feng; Chen, Yun-Dai^*; Zheng, Mei-Li; Yang, Xin-Chun; Xu, Xi-Ping; Huo, Yong

来源：BLOOD PRESSURE, 2015, 24(6): 340-346.

DOI：10.3109/08037051.2014.997089

• Homocysteine
• hypertension
• pulse wave velocity

The aim of the study was to examine the associations among plasma total homocysteine (tHcy) and blood pressure (BP) stages and brachial-ankle pulse wave velocity (ba-PWV) in a Chinese rural community population. In this cross-sectional study, 2148 rural community subjects with normotension and mild hypertension (HTN) were classified into four groups according to ba-PWV level. Multivariate regression showed that ba-PWV was significantly and independently correlated with tHcy (beta = 5.32, p < 0.001) in the entire study population. Moreover, ba- PWV showed a significant increase with increasing plasma tHcy level in subjects with both high normal BP and grade 1 HTN (p < 0.05). Compared with optimal BP stage, ba- PWV was significantly associated with high normal BP stage (beta = 193, p < 0.001) and grade 1 HTN (beta = 413, p < 0.001). There was a statistical interaction effect between high normal BP stage and optimal BP stage (p = 0.045). The similar result was found between subjects with optimal BP and those with grade 1 HTN (p = 0.037). In conclusion, tHcy was independently correlated with ba-PWV in subjects with high normal BP and grade 1 HTN. High normal BP and grade 1 HTN may worsen the impact of tHcy on arterial stiffness in a Chinese rural community population.

• 出版日期2015
• 单位中国人民解放军总医院; 北京大学; 首都医科大学; 安徽医科大学