Mitochondrial sirtuins: regulators of protein acylation and metabolism

作者：He Wenjuan; Newman John C; Wang Margaret Z; Ho Linh; Verdin Eric^*

来源：Trends in Endocrinology and Metabolism, 2012, 23(9): 467-476.

DOI：10.1016/j.tem.2012.07.004

• mitochondria
• sirtuins
• lysine acylation
• metabolism

Sirtuins are NAD(+)-dependent protein deacetylases and have been implicated in the regulation of metabolism, stress responses, and aging. Three sirtuins are located in mitochondria: SIRT3, 4, and 5. SIRT3 deacetylates and regulates the enzymatic activity of many metabolic enzymes in mitochondria, whereas SIRT5 removes two novel post-translational modifications, lysine malonylation and succinylation. Here, we review the current knowledge of how mitochondrial sirtuins function in metabolism and metabolic diseases, and offer a conceptual model how they may regulate mitochondrial function through distinct deacylation activities (deacetylation, demalonylation, or desuccinylation).

• 出版日期2012-9