Lyn sustains oncogenic signaling in chronic lymphocytic leukemia by strengthening SET-mediated inhibition of PP2A

作者：Zonta Francesca; Pagano Mario Angelo; Trentin Livio; Tibaldi Elena; Frezzato Federica; Trimarco Valentina; Facco Monica; Zagotto Giuseppe; Pavan Valeria; Ribaudo Giovanni; Bordin Luciana; Semenzato Gianpietro; Brunati Anna Maria

来源：Blood, 2015, 125(24): 3747-3755.

DOI：10.1182/blood-2014-12-619155

<jats:title>Key Points</jats:title>
<jats:p>Cytosolic HSP90-bound Lyn mediates resistance to apoptosis by strengthening PP2A/SET interaction in CLL cells. FTY720-analogues antagonizing the PP2A/SET interaction and Lyn inhibitors may provide a therapeutic approach of CLL.</jats:p>

• 出版日期2015-6-11
• 单位University of Padua