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摘要
Objective: To investigate the expression and significance of serum interleukin-2 (IL-2), interferon-gamma (IFN-gamma), and serum-specific antibodies in children with atopic dermatitis (AD). Methods: A total of 80 children with AD were selected as Group AD, and 80 infants and young children receiving physical examinations at the same period were selected as the control group. Enzyme-linked immunosorbent assay (ELISA) was used to detect immunoglobulin G (IgG) and immunoglobulin E (IgE) antibodies to allergens as well as the levels of IL-2 and IFN-gamma in the serum. The levels of IgG antibodies, IgE antibodies, IL-2, and IFN-gamma were compared between the two groups. Results: The concentration of IFN-gamma in the peripheral blood of the children with AD was lower than that of normal population. The difference was statistically significant (t=9.89, P=0.020). The concentration of IL-2 in the peripheral blood of the children with AD was higher than that of normal population. The difference was statistically significant (t=21.69, P<0.001). Children with AD showed relatively high positive rates of IgG antibodies to allergens: milk (43.8%), eggs (37.5%) and soybeans (10.0%), and relatively high positive rates of IgE antibodies to the milk (38.8%), eggs (41.3%) and shrimp (21.3%). The positive rates of IgE antibodies to the fish and the shrimp were obviously higher than those of IgG antibodies for children with AD. The differences were statistically significant (both P<0.05). The children with AD had significantly higher positive rates of IgG antibodies to the milk and the eggs than the control group (both P<0.05). They had remarkably higher positive rates of IgE antibodies to the milk, eggs, shrimp, wheat and pork than the control group (all P<0.05). There was a positive correlation between IgG and IgE (r=0.38, P=0.030), a negative correlation between IFN-gamma and IL-2 (r=-0.01, P=0.040), a negative correlation between IFN-gamma and IgE (r=-0.47, P=0.020) and a positive correlation between IL-2 and IgE (r=0.53, P=0.020). Conclusion: Food allergens and inhaled allergens are important causes of AD in children. It is rapid and convenient to detect IgE and IgG antibodies and the allergens of Group AD can be detected effectively. The changes in the levels of serum IL-2 and IFN-gamma play a certain role in the pathogenic process of patients with AD. Early and effective environmental control is very important for treating AD in children and preventing the occurrence of allergic diseases in the respiratory tract.
- 出版日期2018
- 单位汕头大学
