New Triterpenoid Saponins from the Roots of Saponaria officinalis

作者：Moniuszko Szajwaj Barbara^*; Pecio Lukasz; Kowalczyk Mariusz; Simonet Ana M; Macias Francisco A; Szumacher Strabel Malgorzata; Cieslak Adam; Oleszek Wieslaw; Stochmal Anna

来源：Natural Product Communications, 2013, 8(12): 1687-1690.

• Saponaria officinalis L.
• Caryophyllaceae
• Triterpenoid saponins
• NMR

Three new triterpenoid saponins (1-3), along with nine known saponins, were isolated from the roots of Saponaria officinalis L. Two of them: vaccaroside D (4) and dianchinenoside B (5) are known, but not previously reported for S. officinalis, and seven others: saponarioside C (6), D (7), F (8), G (9), I (10), K (11), and L (12) have been previously isolated from this plant. The structures of the new saponins were established as 3-O-beta-D-xylopyranosyl-16 alpha-hydroxygypsogenic acid-28-O-[beta-D-glucopyranosyl-(1 -%26gt; 6)]-beta-D-glucopyranoside (1), 3-O-beta-D-xylopyranosyl-16 alpha-hydroxygypsogenic acid-28-O-[beta-D-glucopyranosyl-(1 -%26gt; 3)]-[alpha-D-galactopyranosyl-(1 -%26gt; 6)-alpha-D-galactopyranosyl-(1 -%26gt; 6)-beta-D-glucopyranosyl-(1 -%26gt; 6)]-beta-D-glucopyranoside (2) and 3-O-beta-D-xylopyranosyl-gypsogenic acid-28-O-[beta-D-glucopyranosyl-(1 -%26gt; 3)]-[6-O-(3-hydroxy-3-methylglutaryl)-beta-D-glucopyranosyl-(1 -%26gt; 6)]-beta-D-glucopyranoside (3). Their structures were elucidated by extensive spectroscopic methods, including 1D- (H-1, C-13) and 2D-NMR (D QF-COSY, TOCSY, ROESY, HSQC and HMBC) experiments, as well as high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), ESI-MS/MS and acid hydrolysis.

• 出版日期2013-12