An Anatomically Customizable Computational Model Relating the Visual Field to the Optic Nerve Head in Individual Eyes

作者：Denniss Jonathan; McKendrick Allison M; Turpin Andrew^*

来源：Investigative Ophthalmology & Visual Science, 2012, 53(11): 6981-6990.

DOI：10.1167/iovs.12-9657

PURPOSE. To present a computational model mapping visual field (VF) locations to optic nerve head (ONH) sectors accounting for individual ocular anatomy, and to describe the effects of anatomical variability on maps produced.
METHODS. A previous model that related retinal locations to ONH sectors was adapted to model eyes with varying axial length, ONH position and ONH dimensions. Maps (n = 11,550) relating VF locations (24-2 pattern, n = 52 non-blind-spot locations) to 1 degrees ONH sectors were generated for a range of clinically plausible anatomical parameters. Infrequently mapped ONH sectors (5%) were discarded for all locations. The influence of anatomical variables on the maps was explored by multiple linear regression.
RESULTS. Across all anatomical variants, for individual VF locations (24-2), totalnumber of mapped 1 degrees ONH sectors ranged from 12 to 90. Forty-one locations varied more than 30 degrees. In five nasal-step locations, mapped ONH sectors were bimodally distributed, mapping to vertically opposite ONH sectors depending on vertical ONH position. Mapped ONH sectors were significantly influenced (P < 0.0002) by axial length, ONH position, and ONH dimensions for 39, 52, and 30 VF locations, respectively. On average across all VF locations, vertical ONH position explained the most variance in mapped ONH sector, followed by horizontal ONH position, axial length, and ONH dimensions.
CONCLUSIONS. Relations between ONH sectors and many VF locations are strongly anatomy-dependent. Our model may be used to produce customized maps from VF locations to the ONH in individual eyes where some simple biometric parameters are known. (Invest Ophthalmol Vis Sci. 2012;53:6981-6990) DOI: 10.1167/iovs.12-9657

• 出版日期2012-10