科研之友
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摘要
A general approach is introduced to optimize experiments for the analysis of spin systems in the presence of chemical exchange. Rather than optimizing individual pulse sequence elements, such as refocusing pulses, entire relaxation dispersion sequences are optimized in the form of a single shaped pulse. This is achieved by defining a performance index that is only based on the remaining signal after the relaxation dispersion sequence for a range of exchange, relaxation, offset, and if inhomogeneity parameters. The approach is demonstrated by optimizing energy-limited broadband relaxation dispersion sequences that closely approach the overall effect of ideal CPMG sequences. As illustrated both theoretically and experimentally, significant improvements are found compared to standard amplitude or energy limited CPMG sequences.
- 出版日期2017-9
