Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis

作者：Markova Roumiana^*; Drenska Rumiana; Minchev Petko; Todorova Yana; Ciccozzi Massimo; Amicosante Massimo

来源：New Microbiologica, 2011, 34(1): 81-85.

• Children
• Tuberculosis
• QuantiFERON
• IGRA

QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-gamma responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. OFT-IT responses to TB-specific antigens are not compromised with young age.

• 出版日期2011-1