A novel recombinant human thrombopoietin therapy for the management of immune thrombocytopenia in pregnancy

作者：Kong, Zhangyuan; Qin, Ping; Xiao, Shan; Zhou, Hai; Li, Hong; Yang, Renchi; Liu, Xiaofan; Luo, Jianmin; Li, Zhichun; Ji, Guochao; Cui, Zhongguang; Bai, Yusheng; Wu, Yuxia; Shao, Linlin; Peng, Jun^*; Ma, Jun^*; Hou, Ming^*

来源：Blood, 2017, 130(9): 1097-1103.

DOI：10.1182/blood-2017-01-761262

• INFLAMMATORY-BOWEL-DISEASE
• CHRONIC ITP
• CONTROLLED-TRIAL
• DOUBLE-BLIND
• PURPURA
• ROMIPLOSTIM
• ANTIBODIES
• PHARMACOKINETICS
• AUTOANTIBODIES
• AZATHIOPRINE

The aim of this study was to determine the safety and efficacy of recombinant human thrombopoietin (rhTPO) for the management of immune thrombocytopenia (ITP) during pregnancy. Pregnant patients with ITP were enrolled in the study if they had a platelet count less than 30-100 x 10(9)/L, were experiencing bleeding manifestations, had failed to respond to corticosteroids and/or intravenous immunoglobulin (IVIG), and had developed refractoriness to platelet transfusion. Thirty-one patients received rhTPO at an initial dose of 300 U/kg once daily for 14 days. Twenty-three patients responded (74.2%), including 10 complete responders (> 100310(9) /L) and 13 responders (30-1003 10(9) /L). It appears that rhTPO ameliorated the bleeding symptoms remarkably, even in the nonresponders. rhTPO was well tolerated. Dizziness, fatigue, and pain at an injection site were reported in 1 patient each. No congenital disease or developmental delays were observed in the infants in a median follow-up of 53 (range, 39-68) weeks. In conclusion, rhTPO is a potentially safe and effective treatment choice for patients with ITP during pregnancy. Ourwork has paved thewayfor further studyonthe clinical application ofrhTPOandother thrombopoietic agents for themanagement of ITP during pregnancy.

• 出版日期2017-8-31
• 单位哈尔滨市第一医院; 中国医学科学院北京协和医院; 实验血液学国家重点实验室; 河北医科大学; 北京协和医学院; 山东大学; 青岛大学