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A novel recombinant human thrombopoietin therapy for the management of immune thrombocytopenia in pregnancy
Kong Zhangyuan
Qin Ping
Xiao Shan
Zhou Hai
Li Hong
Yang Renchi
Liu Xiaofan
Luo Jianmin
Li Zhichun
Ji Guochao
Cui Zhongguang
Bai Yusheng
Wu Yuxia
Shao Linlin
Peng Jun
Ma Jun
Hou Ming
Blood, 2017, 130(9): 1097-1103.
The aim of this study was to determine the safety and efficacy of recombinant human thrombopoietin (rhTPO) for the management of immune thrombocytopenia (ITP) during pregnancy. Pregnant patients with ITP were enrolled in the study if they had a platelet count less than 30-100 x 10(9)/L, were experiencing bleeding manifestations, had failed to respond to corticosteroids and/or intravenous immunoglobulin (IVIG), and had developed refractoriness to platelet transfusion. Thirty-one patients received rhTPO at an initial dose of 300 U/kg once daily for 14 days. Twenty-three patients responded (74.2%), including 10 complete responders (> 100310(9) /L) and 13 responders (30-1003 10(9) /L). It appears that rhTPO ameliorated the bleeding symptoms remarkably, even in the nonresponders. rhTPO was well tolerated. Dizziness, fatigue, and pain at an injection site were reported in 1 patient each. No congenital disease or developmental delays were observed in the infants in a median follow-up of 53 (range, 39-68) weeks. In conclusion, rhTPO is a potentially safe and effective treatment choice for patients with ITP during pregnancy. Ourwork has paved thewayfor further studyonthe clinical application ofrhTPOandother thrombopoietic agents for themanagement of ITP during pregnancy.
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