Physics of lumen growth

作者：Dasgupta Sabyasachi; Gupta Kapish; Zhang Yue; Viasnoff Virgile^*; Prost Jacques^*

来源：Proceedings of the National Academy of Sciences, 2018, 115(21): E4751-E4757.

DOI：10.1073/pnas.1722154115

• lumenogenesis
• osmotic pressure
• morphogenesis

We model the dynamics of formation of intercellular secretory lumens. Using conservation laws, we quantitatively study the balance between paracellular leaks and the build-up of osmotic pressure in the lumen. Our model predicts a critical pumping threshold to expand stable lumens. Consistently with experimental observations in bile canaliculi, the model also describes a transition between a monotonous and oscillatory regime during luminogenesis as a function of ion and water transport parameters. We finally discuss the possible importance of regulation of paracellular leaks in intercellular tubulogenesis.

• 出版日期2018-5-22