Antimicrobial silica particles loaded with quaternary ammonium polyethyleneimine network

作者：Farah Shady; Aviv Oren; Laout Natalia; Ratner Stanislav; Beyth Nurit; Domb Abraham J^*

来源：Polymers for Advanced Technologies, 2014, 25(6): 689-692.

DOI：10.1002/pat.3260

• polyethylenimine (PEI)
• silica particles
• interpenetrating polymer network
• antimicrobial surface

Silica particles functionalized with quaternary ammonium groups were prepared by interpenetrating polyethylenimine (PEI) into silica particles and crosslinking with diiodopentane, followed by octyliodide alkylation and methyliodide quaternarization (S-QA-PEI). The synthesized S-QA-PEI particles were identified with a slight particle size increase of 2-3 mu m. Different ratios of PEI: silica particles were prepared and analyzed. While silica particles are negatively charged, -16.7 +/- 5.11 mV, the prepared S-QA-PEI particles are positively charged, +50-60 mV. These particles were embedded in poly(ethylene vinyl acetate) and poly(ethylene methacrylic acid) coatings which exhibited strong antibacterial activity.

• 出版日期2014-6