Decreased level of serum autoantibody against LG72 is a biosignature of amyotrophic lateral sclerosis

作者：Hwang, Chi-Shin; Tsai, Chon-Haw; Liu, Guan-Ting; Li, Weimin; Chang, Hao-Teng^*

来源：Biomarkers in Medicine, 2016, 10(1): 73-79.

DOI：10.2217/bmm.15.80

• amyotrophic lateral sclerosis
• autoantibody
• LG72

Aim: LG72 can increase mitochondrial ROSs and oxidative stress has been implicated in the pathophysiology of amyotrophic lateral sclerosis (ALS). The serum level of LG72 or LG72-related molecules might therefore be associated with ALS. Here, we aim to determine the serum autoantibody against LG72 has potential as a biomarker for the diagnosis of ALS. Materials: Seventy-eighty patients with ALS, 45 patients with AD, 43 patients with PD and 88 healthy adults were enrolled. Results: The concentration of serum autoantibody against LG72 was more than fourfold lower in ALS than other control groups (p < 0.001). The AUC was 0.9627 when the cut-off value for autoantibody concentration was 0.167 g/ml. Conclusion: This finding suggests that the autoantibody against LG72 might serve as a surrogate biomarker for ALS.

• 出版日期2016
• 单位中国医科大学; 温州医科大学