Novel Trends in Genetics: Transposable Elements and Their Application in Medicine

作者：Rajabpour Fatemeh Vand; Raoofian Reza; Habibi Laleh; Akrami Seyed Mohammad; Tabrizi Mina^*

来源：Archives of Iranian Medicine, 2014, 17(10): 702-712.

• Gene therapy
• genetic transposition
• induced pluripotent stem cell (iPSC)
• transposable elements (TEs)
• transposable element based vectors (TEV)

Forty-five percent of the human genome is composed of Transposable Elements (TEs); therefore, TEs have had an undisputed impact on evolution of the most evolved creature by a very simple mechanism of action. Scientists have been studying this simple mechanism of action and are currently using it to develop-efficient and safe gene delivery systems especially for treatment of diseases. TEs have also been used safely in generating induced Pluripotent Stem Cells (iPSC) for regenerative medicine, which-opens the,door to a world-of possibilities in our approach in trying to wrestle with many Challenges in medicine: The PiggyBac (PB) system has yielded more success in generation of induced pluripotent stem cells in regenerative medicine, and: the Sleeping Beauty (SB) has been more successful in Gene Therapy. Recent advances are indicative of more good news to come regarding the potential heights of successes achievable by the use of the TE-base systems.

• 出版日期2014-10