A High-Resolution In Vivo Atlas of the Human Brain's Serotonin System

作者：Beliveau Vincent; Ganz Melanie; Feng Ling; Ozenne Brice; Hojgaard Liselotte; Fisher Patrick M; Svarer Claus; Greve Douglas N; Knudsen Gitte M^*

来源：Journal of Neuroscience, 2017, 37(1): 120-128.

DOI：10.1523/JNEUROSCI.2830-16.2017

• 5-HT
• atlas
• autoradiography
• MRI
• mRNA
• PET

The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals. Comparison of the regional PET binding measures with postmortem human brain autoradiography outcomes showed a high correlation for the five 5-HT targets and this enabled us to transform the atlas to represent protein densities (in picomoles per milliliter). We also assessed the regional association between protein concentration and mRNA expression in the human brain by comparing the 5-HT density across the atlas with data from the Allen Human Brain atlas and identified receptor-and transporter-specific associations that show the regional relation between the two measures. Together, these data provide unparalleled insight into the serotonin system of the human brain.

• 出版日期2017-1-4