Hydrogenolysis of N- and O-protected hydroxyazetidines over palladium: Efficient and selective methods for ring opening and deprotecting reactions

作者：Kovacs Ervin; Faigl Ferenc; Mucsi Zoltan; Nyerges Miklos; Hegedus Laszlo^*

来源：Journal of Molecular Catalysis A: Chemical , 2014, 395: 217-224.

DOI：10.1016/j.molcata.2014.08.027

• Azetidines
• Ring opening
• Hydrogenolysis
• Palladium
• Solvent effects

Some N- and O-protected hydroxyazetidine derivatives were hydrogenated to the corresponding amines or aminoalcohols over a Pd/C catalyst, in different solvents (methanol, dichloromethane, tetrahydrofuran), at 30-60 degrees C and 1-10 bar. These amino compounds, formed during hydrogenolytic ring opening and/or deprotecting reactions, are potential starting materials for preparing optically active, practically important pyrrolidine derivatives.

• 出版日期2014-12
• 单位河北医科大学