A Concise Route to Pyridines from Hydrazides by Metal Carbene N-H Insertion, 1,2,4-Triazine Formation, and Diels-Alder Reaction

作者：Shi Baolu; Lewis William; Campbell Ian B; Moody Christopher J^*

来源：Organic Letters, 2009, 11(16): 3686-3688.

DOI：10.1021/ol901502u

simple, new three-step sequence for the conversion of hydrazides into pyridines is reported in which the key steps are N-H insertion by a copper carbene intermediate derived from alpha-diazo-beta-ketoesters into the hydrazide, reaction with ammonium acetate to give 1,2,4-triazines, followed by Diels-Alder reaction with norbornadlene.

• 出版日期2009-8-20