The spectrum of drug-related colitides: Important entities, though frequently overlooked

作者：Villanacci Vincenzo; Casella Giovanni; Bassotti Gabrio^*

来源：Digestive and Liver Disease, 2011, 43(7): 523-528.

DOI：10.1016/j.dld.2010.12.016

• Colitis
• Drug colitis
• Pathology

Background: There is at present a relative lack of knowledge concerning drug-related colitides, although these may be not infrequent entities in clinical practice.
Aims: To assess the frequency and the clinical-pathological subtypes of drug-related colitides in a gastrointestinal pathology referral centre.
Methods: All charts of endoscopic biopsy samples referred for colitis in a eight-year period were reviewed. To be classified as drug related colitis, patients' charts should report the use of any drug in a two month period before colonoscopy and no other obvious cases of colitis be present. For analysis, we considered only patients taking one drug in this period.
Results: We found 122 cases of drug-related colitis out of 3877 charts reviewed (3% of the overall colitis group). These cases were represented by microscopic colitis (50%), eosinophil rich infiltrate of the left colon (34%), ischemic colitis (11%), pseudomembranous colitis (3%), apoptotic colopathy (2%). The drugs most frequently associated with these colitides were represented by non-steroid anti-inflammatory drugs.
Conclusion: It is important to raise awareness concerning drug-related colitides, to avoid diagnostic errors and provide a better therapeutic approach to patients with these conditions.

• 出版日期2011-7