Protein glycation as a pathological mechanism in diabetes

作者：Simm A^*; Navarrete Santos A; Hofmann B; Bushnaq H; Nass N

来源：Zeitschrift fur Gerontologie und Geriatrie, 2012, 45(2): 95-99.

DOI：10.1007/s00391-011-0282-2

• Advanced glycation end products
• Blood glucose
• Diabetes complications
• Inflammation
• Biomarkers

The incidence of diabetes has increased in the recent years. Diabetes is characterized by increased sugar concentrations in the blood. Due to this dysregulation, more carbohydrate-induced modification of proteins - so-called advanced glycation end products (AGEs) - are formed endogenously by non-enzymatic reactions. These are discussed to be at least in part responsible for diabetes-associated diseases. The accumulation of AGEs in the tissue can be used as a biomarker for patient outcome. In contrast, the effects of the uptake of AGEs from nutrition are still unclear.

• 出版日期2012-2