Asymmetric Homoenolate Additions to Acyl Phosphonates through Rational Design of a Tailored N-Heterocyclic Carbene Catalyst

作者：Jang Ki Po; Hutson Gerri E; Johnston Ryne C; McCusker Elizabeth O; Cheong Paul H Y^*; Scheidt Karl A

来源：Journal of the American Chemical Society, 2014, 136(1): 76-79.

DOI：10.1021/ja410932t

A highly selective NHC-catalyzed synthesis of gamma-butyrolactones from the fusion of enals and alpha-ketophosphonates has been developed. Computational modeling of competing transition states guided a rational design strategy to achieve enhanced levels of enantioselectivity with a new tailored C-1-symmetric biaryl-saturated imidazolium-derived NHC catalyst.

• 出版日期2014-1-8
• 单位西北大学