Dynamic changes of intracellular Ca2+ content of rats brain after traumatic brain injury and its correlation with the concentration of calcitonin gene‐related peptide

作者：Wen Xue; Hubin Duan; Xiaohong Qiao; Chunyan Hao; Xiaoyi Zhang; Yanrong Du; zhigang feng; Zhiyong Guo; Junping Zhen; Youliang Li

来源：The FASEB Journal, 2020, 34(S1): 1-1.

DOI：10.1096/fasebj.2020.34.s1.00511

• Calcium overload
• Calcitonin gene-related peptide
• Traumatic brain injury

Objective(#br)To investigate the dynamic changes of intracellular Ca2+ content of rats brain after traumatic brain injury (TBI) and its correlation with the concentration of calcitonin gene‐related peptide (CGRP)(#br)Methods(#br)The rats model with TBI was prepare by Feeney’s methods. 144 male Wistar rats were randomly divided into Sham operation group(Sham group, 36 rats) and traumatic brain injury group (TBI group, 108 rats ). Above two groups subdivided into six groups by 2h,6h,12h,24h, 48h and 72h after TBI( 6 rats in each group. The calcium content in the rats brain cells were detected by laser scanning confocal microscope, and the CGRP concentration in plasma of rats were got by enzyme‐linked immunosorbent assay.(#br)Results(#br)There were significant differences of calcium fluorescence intensity in the rats brain cells between the Sham group and the TBI group (P<0.05). In the meantime there were also significant differences of the CGRP concentration in plasma of rats between the Sham group a...

• 出版日期2020