A brief history of autophagy from cell biology to physiology and disease

作者：Mizushima, Noboru^*

来源：Nature Cell Biology, 2018, 20(5): 521-527.

DOI：10.1038/s41556-018-0092-5

• GENOME-WIDE ASSOCIATION
• SELECTIVE AUTOPHAGY
• ENDOPLASMIC-RETICULUM
• CYTOSOLIC PROTEINS
• CARGO RECOGNITION
• PICHIA-PASTORIS
• CROHN-DISEASE
• ULK1 COMPLEX
• MEMBRANE
• DEGRADATION

The field of autophagy research has developed rapidly since the first description of the process in the 1960s and the identification of autophagy genes in the 1990s. Autophagy is now increasingly studied at the level of organismal pathophysiology and is being connected to the medical sciences. This Historical Perspective describes a brief history of autophagy and discusses unanswered cell biological questions in the field.

• 出版日期2018-5