Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach

作者：Dana Dibyendu; De Shatarupa; Rathod Pratikkumar; Davalos Anibal R; Novoa Daniel A; Paroly Suneeta; Torres Viviana M; Afzal Nisar; Lankalapalli Ravi S; Rotenberg Susan A; Chang Emmanuel J; Subramaniam Gopal; Kumar Sanjai^*

来源：Chemical communications, 2014, 50(74): 10875-10878.

DOI：10.1039/c4cc04037f

A hybrid-design approach is undertaken to develop a highly potent and selective inhibitor of human cathepsin L. Studies involving human breast carcinoma MDA-MB-231 cells establish that this inhibitor can successfully block intracellular cathepsin L activity, and retard the cell-migratory potential of these highly metastatic cells.

• 出版日期2014