High Prevalence of Carbapenemase-Producing Enterobacteriaceae among Hospitalized Children in Luanda, Angola

作者：Kieffer Nicolas; Nordmann Patrice; Aires de Sousa Marta; Poirel Laurent^*

来源：Antimicrobial Agents and Chemotherapy, 2016, 60(10): 6189-6192.

DOI：10.1128/AAC.01201-16

This study aimed to evaluate the prevalence of carbapenemase-producing Enterobacteriaceae in Luanda, Angola. A total of 157 rectal samples were collected from children visiting a pediatric hospital in Luanda in March 2015. Fifty-seven imipenem-nonsusceptible enterobacterial isolates were recovered, most of which were non-clonally related. The bla(OXA-181) (50/57) and bla(NDM-1) (7/57) carbapenemase genes were identified. Notably, OXA-181-producing Escherichia coli isolates rarely coproduced extended-spectrum beta-lactamases and consequently remained susceptible to broad-spectrum cephalosporins. The bla(OXA-181) gene was always located on an IncX3 plasmid, while the bla(NDM-1) gene was located on either IncFIA or IncA/C plasmids. The study identified a high prevalence of OXA-181 among hospitalized children in Angola.

• 出版日期2016-10