A New Cytotoxic Gymnomitrane Sesquiterpene from Ganoderma lucidum Fruiting Bodies

作者：Pham Thanh Binh; Descoutures Dimitri; Nguyen Hai Dang; Nguyen Phuong Dai Nguyen; Nguyen Tien Dat^*

来源：Natural Product Communications, 2015, 10(11): 1911-1912.

DOI：10.1177/1934578x1501001125

• Ganoderma lucidum
• Gymnomitrane
• Sesquiterpene
• EGFR-TKI

A new gymnomitrane-type sesquiterpenoid, gymnomitrane-3 alpha,5 alpha,9 beta,15-tetrol (1), was isolated from the fruiting body of Ganoderma lucidum. Its structure was elucidated using spectroscopic methods. This compound significantly inhibited the growth of epidermal growth factor receptor-tyrosine kinase inhibitor EGFR-TKI-resistant human lung cancer A549 and human prostate cancer PC3 cell lines.

• 出版日期2015-11