科研之友
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摘要
Transforming Growth Factor beta (TGF beta) signaling has a complex influence on cell proliferation, acting to stop cell division in differentiating cells, but also promoting cell division in immature cells. The activity of the pathway in Drosophila is mostly required to stimulate the proliferation of neural and epithelial tissues. Most interestingly, this function is not absolutely required for cell division, but it is needed for these tissues to reach their correct size. It is not known how TGF beta signaling promotes cell division in imaginal discs, or what the interactions between TGF beta activity and other signaling pathways regulating cell proliferation are. In this work, we have explored the disc autonomous function of TGF beta that promotes wing imaginal disc growth. We have studied the genetic interactions between TGF beta signaling and other pathways regulating wing disc growth, such as the Insulin and Hippo/Salvador/Warts pathways, as well as cell cycle regulators. We have also identified a collection of TGF beta candidate target genes affecting imaginal growth using expression profiles. These candidates correspond to genes participating in the regulation of a variety of biochemical processes, including different aspects of cell metabolism, suggesting that TGF beta could affect cell proliferation by regulating the metabolic fitness of imaginal cells.
- 出版日期2017-5
