Postprandial microvascular function deteriorates in parallel with gradual worsening of insulin sensitivity and glucose tolerance in men with the metabolic syndrome or type 2 diabetes

作者：van Genugten R E^*; Serne E H; Heymans M W; van Raalte D H; Diamant M

来源：Diabetologia, 2013, 56(3): 583-587.

DOI：10.1007/s00125-012-2783-y

• Capillary video microscopy
• Glucose tolerance
• Insulin resistance
• Metabolic syndrome
• Microcirculation
• Microvascular function
• Mixed-meal test
• Postprandial hyperglycaemia
• Type 2 diabetes mellitus

Hyperinsulinaemia-induced whole-body glucose uptake during a euglycaemic-hyperinsulinaemic clamp is partly mediated by increased capillary density. We hypothesised that physiological insulinaemia in response to a mixed meal may also enhance microvascular function, and that this may be impaired in insulin-resistant individuals and patients with type 2 diabetes. %26lt;br%26gt;Twelve men with uncomplicated type 2 diabetes, 13 with metabolic syndrome and 12 age-matched healthy normoglycaemic controls, mean age 57 +/- 6 years, underwent skin capillary video microscopy before and 60 and 120 min following a standardised mixed meal to measure baseline capillary density (BCD) and capillary density during post-occlusive peak reactive hyperaemia (PRH), also termed capillary recruitment. Oral glucose insulin sensitivity (Matsuda index) and postprandial hyperglycaemia (2 h AUC(glucose)) were calculated. %26lt;br%26gt;Fasting BCD was similar among groups, but fasting PRH was lowest in diabetes (p %26lt; 0.05). Postprandially, both BCD and PRH increased in all groups (p %26lt; 0.001); however, the meal-related increase in BCD was significantly lower in diabetes and metabolic syndrome vs controls (both p %26lt; 0.05). At all time points, postprandial PRH was lower in both diabetes and metabolic syndrome vs controls (both p %26lt; 0.05). In pooled analysis, postprandial mean PRH correlated with Matsuda index (r = 0.386, p = 0.018) and inversely with 2 h AUC(glucose) (r = -0.336, p = 0.042). %26lt;br%26gt;Gradual deterioration in meal-related capillary recruitment was paralleled by decreasing insulin sensitivity and postprandial hyperglycaemia, as assessed in healthy normoglycaemic men, men with the metabolic syndrome and those with type 2 diabetes. These findings suggest that in both impaired glucose tolerance and in overt diabetes microvascular dysfunction might contribute to postprandial dysglycaemia. %26lt;br%26gt;ClinicalTrials.gov NCT00721552.

• 出版日期2013-3