Antioxidant Activities of Plumbagin and Its Cu (II) Complex

作者：Tan, Mingxiong^*; Liu, Yancheng; Luo, Xujian; Chen, Zhenfeng; Liang, Hong

来源：Bioinorganic Chemistry and Applications, 2011, 2011: 898726.

DOI：10.1155/2011/898726

• IRON CHELATORS

Plumbagin and its Cu (II) complex [Cu (plumbagin) 2] center dot H2O have been synthesized, and their antioxidant activities towards the inhibitory effect on DPPH free radical, reducing power, total antioxidant capacity, and inhibition on lipid peroxidation were investigated. Plumbagin and its Cu (II) complex were found to exhibit scavenging activities on DPPH radical with the inhibitory rate of 41% and 24%, respectively. The reducing power of plumbagin was outstanding at the concentrations of 1.0, 1.5, and 2.0 mg/mL, compared to Cu (II) complex and synthetic antioxidant 2,6-di-ter-butyl-4-methylphenol (BHT); the highest level reached 1.333 for plumbagin and 0.581 for Cu (II) complex. Also, the inhibition on lipid peroxidation of plumbagin was higher than that of Cu (II) complex and BHT, 46.4% for plumbagin and 24.5% for Cu (II) complex. The results give a strong impact for designing anticancer drugs, combined with their potential cytotoxic and antioxidant activities, which can be targeted selectively against cancer cells and increase their therapeutic index and additional advantages over other anticancer drugs.

• 出版日期2011
• 单位广西师范大学; 玉林师范学院