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AIM: To determine whether glaucoma patients exhibit an abnormal melatonin concentration in serum and the effects of psychiatric disorders caused by glaucoma in melatonin secretion. @@@ METHODS: A sample of 80 primary angle-closure glaucoma (PACG) patients, 120 primary open angle glaucoma (POAG) patients, and 120 normal controls were enrolled in this study. All the participants were asked to complete the following questionnaires: Pittsburgh sleep quality index (PSQI), self-rating anxiety scale (SAS), and self-rating depression scale (SDS). Variance analysis was used to compare the subscores between the groups. After that, we chose 58 patients with primary glaucoma and 20 non-glaucoma control patients to collect their serum samples at 7-10 a.m. Serum melatonin levels were measured using enzyme linked immunosorbent assay (ELISA). @@@ RESULTS: Of all participants, the scores of PSQI, SAS, and SDS in PACG and POAG group were 9.38 +/- 0.40, 46.08 +/- 8.99, 51.11 +/- 10.72 and 7.43 +/- 0.35, 45.42 +/- 9.87, 49.04 +/- 12.24 respectively, significantly higher than those in control group (4.16 +/- 0.28, 35.49 +/- 9.18, 40.31 +/- 13.08). The serum melatonin levels in PACG (37.29 +/- 2.99 pg/mL) and POAG (35.97 +/- 3.64 pg/mL) were significantly higher than the controls (29.96 +/- 3.94 pg/mL) (P<0.001). But no difference was found between the PACG and POAG (P=0.216). Glaucoma patients with sleep disorders, anxiety and depression were more likely resulting in the increase of melatonin levels. @@@ CONCLUSION: There is a significant increase in serum melatonin levels in glaucoma patients compared to the controls especially in glaucoma patients with psychiatric disorders such as sleep disorders, anxiety and depression.
- 出版日期2018-8-18
- 单位复旦大学
