An Intramolecular [2+2] Cycloaddition of Ketenimines via Palladium-Catalyzed Rearrangements of N-Allyl-Ynamides

作者：DeKorver Kyle A; Hsung Richard P^*; Song Wang Ze; Wang Xiao Na; Walton Mary C

来源：Organic Letters, 2012, 14(12): 3214-3217.

DOI：10.1021/ol3013233

A cascade of Pd-catalyzed N-to-C allyl transfer intramolecular ketenimine-[2 + 2] cycloadditions of N-allyl ynamides is described. This tandem sequence is highly stereoselective and the [2 + 2] cycloaddition could be rendered in a crossed or fused manner depending on alkene substitutions, leading to bridged and fused bicycloimines.

• 出版日期2012-6-15