Application of urine proteomics for biomarker discovery in drug-induced liver injury

作者：van Swelm Rachel P L; Kramers Cornelis; Masereeuw Rosalinde; Russel Frans G M^*

来源：Critical Reviews in Toxicology, 2014, 44(10): 823-841.

DOI：10.3109/10408444.2014.931341

• acetaminophen
• diclofenac
• fibrosis
• gel electrophoresis
• hepatocellular injury
• idiosyncratic
• LC-MS/MS
• MALDI-TOF MS
• methotrexate
• oxidative stress

The leading cause of hepatic damage is drug-induced liver injury (DILI), for which currently no adequate predictive biomarkers are available. Moreover, for most drugs related to DILI, the mechanisms underlying the adverse reaction have not yet been elucidated. Urinary protein biomarker candidates for DILI have emerged in the past few years and correlate well with clinical studies for serum DILI biomarkers. The goal of this review was to investigate the use of urine as a source of protein biomarkers for drug-induced liver injury. Finally, we discuss some of the current strategies required to advance the field of biomarker discovery for DILI with respect to appropriate clinical biobanking and adequate translational research.

• 出版日期2014-11