Antibiotic Activity of Iron-Sequestering Polymers

作者：El Gendy Nashwa; Qian Jian; Eshelman Kate; Rivera Mario; Berkland Cory^*

来源：Biomacromolecules, 2015, 16(5): 1480-1488.

DOI：10.1021/bm5016392

Increasing antibiotic resistance has compelled the development of novel antibiotics and adjuvant therapies that enhance the efficacy of existing antibiotics. Iron plays a critical role in bacterial infections, yet the use of iron chelatots as adjuvant therapy With antibiotics has yielded highly variable outcomes. Multivalent polymeric materials offer an alternative approach to band and sequester iron via high avidity interactions: Here, a biomimetic iron seguestering polymer (PAI-DHBA) was synthesized by modifying side chains of cross linked polyallylatnine (cPAI) with 2,3-clihydroicybenzoic acid PAI-DHBA polymer gels with various DHBA Contents showed high iron affinity indices and high Selectivity for iron. The: polymers showed mild antibiotic properties when used to treat established bacterial cultures. Pretreating culture media with PAI-DHBA polymer, however; removed all detectable iron from media and effectively inhibited the growth of Pseudomonas aeruginosa. In addition, bacterial growth was more susceptible to antibiotics Combined with PAI-DHBA, Multivalent polymers that bind and sequester iron, such as PAI-DHBA, offer a promising early intervention or adjuvant to antibiotics.

• 出版日期2015-5