Analysis of Seven Drugs in Human Hair by Hybrid Linear Ion Trap/Orbitrap Mass Spectrometry

作者：Ye Hai-Ying; Zheng Shui-Qing; Liang Chen; Wang Rong; Zhang Yu-Rong; Zhang Ling-Yi; Zhang Wei-Bing; Zhang Run-Sheng^*

来源：Chinese Journal of Analytical Chemistry, 2012, 40(11): 1674-1679.

DOI：10.3724/SP.J.1096.2012.20244

• Linear ion trap/orbitrap mass spectrometry
• Opiates
• Ketamine
• Methadone
• Solid phase extraction
• Ultra high performance liquid chromatography
• Hair

A new method was developed for the determination of seven illicit drugs and metabolites in human hair by ultra high performance liquid chromatograph tandem a linear ion trap-orbitrap hybrid instrument at high mass resolution (UHPLC-LTQ-Orbitrap/MS). After being washed and grinded, the hair samples were soaked in pH 9.2 borate buffer with ultrasonic for 90 min. Then the samples were extracted by solid phase extraction (SPE). High resolution mass spectrometry was applied to reduce matrix interference. Full scanning of electrostatic field orbitrap was applied for quantification of drugs. The limits of detection (LOD) of seven illicit drugs and metabolites in human hair were 0.001-0.02 mu g/g. The method showed a fairly good linearity over the range of 0.05-50 mu g/g (r>0.9975). The spiked recoveries were between 76.1%-109.6%, and the deviation of intra- and inter- day precision was less than 14.9%. The method is simple, high sensitive, and suitable for the determination of illicit drugs in human hair.

• 出版日期2012-11
• 单位司法部司法鉴定科学技术研究所; 华东理工大学