A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig

作者：Yamaguchi Takehiro; Yamazaki Takanori; Kawaguchi Hiroaki; Tawa Masashi; Nakamura Yasuhiro; Shiota Masayuki; Osada Oka Mayuko; Tanimoto Akihide; Okamura Tomio; Miura Katsuyuki; Iwao Hiroshi; Yoshiyama Minoru; Izumi Yasukatsu^*

来源：Journal of Pharmacological Sciences, 2014, 126(2): 168-171.

DOI：10.1254/jphs.14171SC

• metabolic syndrome
• Microminipig
• nitric oxide

Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and N-G-nitro-L-arginine methyl ester (L-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, L-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by L-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by L-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.

• 出版日期2014-10