Anti-inflammatory, analgesic, and antipyretic activities of virgin coconut oil

作者：Intahphuak S^*; Khonsung P; Panthong A

来源：Pharmaceutical Biology, 2010, 48(2): 151-157.

DOI：10.3109/13880200903062614

• Virgin coconut oil (VCO)
• anti-inflammatory
• analgesic
• antipyretic effects

This study investigated some pharmacological properties of virgin coconut oil (VCO), the natural pure oil from coconut [Cocos nucifera Linn (Palmae)] milk, which was prepared without using chemical or high-heat treatment. The anti-inflammatory, analgesic, and antipyretic effects of VCO were assessed. In acute inflammatory models, VCO showed moderate anti-inflammatory effects on ethyl phenylpropiolate-induced ear edema in rats, and carrageenin- and arachidonic acid-induced paw edema. VCO exhibited an inhibitory effect on chronic inflammation by reducing the transudative weight, granuloma formation, and serum alkaline phosphatase activity. VCO also showed a moderate analgesic effect on the acetic acid-induced writhing response as well as an antipyretic effect in yeast-induced hyperthermia. The results obtained suggest anti-inflammatory, analgesic, and antipyretic properties of VCO.

• 出版日期2010-2