A selective and sensitive voltammetric sensor based on molecularly imprinted polymer for the determination of dipyridamole in pharmaceuticals and biological fluids

作者：Javanbakht Mehran^*; Fathollahi Fatemeh; Divsar Faten; Ganjali Mohammad Reza; Norouzi Parviz

来源：Sensors and Actuators B: Chemical , 2013, 182: 362-367.

DOI：10.1016/j.snb.2013.02.097

• Dipyridamole
• Differential pulse adsorptive stripping voltammetry
• Electrochemical sensor
• Biological fluid
• Pharmaceuticals

This study introduces a selective and sensitive method for the determination of dipyridamole (DIP) using differential pulse adsorptive stripping voltammetry (DPASV). This method is based on the electrochemical behavior of DIP at a molecularly imprinted polymer (MIP) modified carbon paste electrode. The modified electrode demonstrated a linear response in the range of 1.0-110 ng mL(-1) of DIP with a detection limit of 0.05 ng mL(-1) under optimal conditions. The proposed method was applied to the DIP determination in tablet and human serum samples and results were satisfying compared with that obtained by HPLC.

• 出版日期2013-6