Association of urinary biomarker COLL2-1NO(2) with incident clinical and radiographic knee OA in overweight and obese women

作者：Landsmeer M L A^*; Runhaar J; Henrotin Y E; van Middelkoop M; Oei E H G; Vroegindeweij D; Reijman M; van Osch G J V M; Koes B W; Bindels P J E; Bierma Zeinstra S M A

来源：Osteoarthritis and Cartilage, 2015, 23(8): 1398-1404.

DOI：10.1016/j.joca.2015.04.011

• Knee
• Osteoarthritis
• Biomarker
• Coll2-1NO(2)

Objective: To investigate the association between urinary biomarker Coll2-1NO(2) (uColl2-1NO(2)) and incident knee OA after 2.5 years follow-up in middle-aged overweight and obese women at high risk for knee osteoarthritis (OA).
Design: Data were used from PROOF, a randomized controlled trial with 2.5 years follow-up evaluating the preventive effects of a diet and exercise program and oral glucosamine sulphate (double blind and placebo controlled), on development of incident knee OA in women with body mass index >= 27 kg/m(2) without signs of knee OA at baseline. Baseline and 2.5 years uColl2-1NO(2) concentrations were assessed with enzyme-linked immunosorbent assay (ELISA). Primary outcome measure was incidence of knee OA in one or both knees, defined as incidence of either Kellgren & Lawrence grade >= 2, joint space narrowing of >= 1.0 mm or knee OA according to the combined clinical and radiographic ACR-criteria. We used binary logistic regression for the association analyses.
Results: 254 women were available for analyses. At 2.5 years follow-up, incident knee OA was present in 72 of 254 women (28.3%). An inversed association was found between baseline uColl2-1NO(2) and incident knee OA at 2.5 years (OR 0.74, 95% CI 0.55-0.99). The concentration at 2.5 years and the change in concentration over 2.5 years did not show significant associations with the outcome.
Conclusions: In overweight and obese middle-aged women, not higher but lower baseline uColl2-1NO(2) concentration was significantly associated with an increased risk for incident knee OA. This interesting but counterintuitive outcome makes further validation of this biomarker warranted.

• 出版日期2015-8