A LINEAGE-SPECIFIC T(1,14)(Q21,Q32) AS AN EARLY EVENT IN DEVELOPMENT OF B-CELL CLONAL EXPANSION

作者：PINKERTON PH^*; REIS MD; DECOTEAU J; SRIGLEY JR; DUBE ID; LONDON B

来源：Cancer Genetics and Cytogenetics, 1992, 64(2): 166-169.

DOI：10.1016/0165-4608(92)90349-D

We report a patient in whom a cell line of 47,XY,+X,t(1;14)(q21;q32) constitution was found in a lymph node excised from the neck. Histologic examination and immunophenotyping both in situ and by flow cytometry failed to confirm a diagnosis of B-cell lymphoma, but Southern analysis indicated the presence of B-cell clonal expansion. These observations support the concept that primary chromosomal abnormalities occur in clonal expansions in the very earliest stages of tumorigenesis.

• 出版日期1992-12