A randomized trial of lottery-based incentives and reminders to improve warfarin adherence: the Warfarin Incentives (WIN2) Trial

作者：Kimmel Stephen E^*; Troxel Andrea B; French Benjamin; Loewenstein George; Doshi Jalpa A; Hecht Todd E H; Laskin Mitchell; Brensinger Colleen M; Meussner Chris; Volpp Kevin

来源：Pharmacoepidemiology and Drug Safety, 2016, 25(11): 1219-1227.

DOI：10.1002/pds.4094

• anticoagulants
• trials
• incentives
• economics
• behavioral
• pharmacoepidemiology
• pharmacoepidemiology

BackgroundPrevious research has suggested that daily lottery incentives could improve medication adherence. Such daily incentives include implicit reminders. However, the comparative effectiveness of reminders alone versus daily incentives has not been tested.
MethodsA total of 270 patients on warfarin were enrolled in a four-arm, multi-center, randomized controlled trial comparing a daily lottery-based incentive, a daily reminder, and a combination of the two against a control group (usual care).
ResultsParticipants in the reminder group had the lowest percentage of time out of target international normalized ratio (INR) range, the primary outcome, with an adjusted odds of an out-of-range INR 36% lower than among those in the control group, 95%CI [7%, 55%]. No other group had a statistically significant improvement in anticoagulation control relative to the control group or to each other. The only group that had significant improvement in incorrect adherence was the lottery group (incorrect adherence: 12.1% compared with 23.7% in the control group, difference of -7.4% 95%CI [-14%, -0.3%]). However, there was no relationship between changes in adherence and anticoagulation control in the lottery group.
ConclusionsAutomated reminders led to the largest improvements in anticoagulation control, although without impacting measured adherence. Lottery-based reminders improved measured adherence but did not lead to improved anticoagulation control.

• 出版日期2016-11